WebNov 28, 2024 · Rotenone is a commonly used insecticidal chemical in agriculture and it is an inhibitor of mitochondrial complex Ⅰ. Previous studies have found that rotenone induces the production of reactive oxygen species (ROS) by inhibiting electron transport in the mitochondria of somatic and germ cells. However, there is little precise information on … WebRotenone has also been shown to induce an ROS-associated cytotoxicity in dopaminergic neurons. 130,131 Through the use of dopaminergic neuroblastoma tumor cells, rotenone has been used to investigate the potential of complex I inhibition to induce the progressive degeneration of dopaminergic neurons associated with Parkinson’s disease. 132 As such, …
Rotenone induces apoptosis in human lung cancer cells by regulating autophagic flux
WebSep 16, 2015 · Rotenone inhibits the electron transfer from complex I to ubiquinone, in this way interfering with the electron transport chain in mitochondria. This chain of events induces increased levels of intracellular reactive oxygen species, which in turn can contribute to acceleration of telomere shortening and induction of DNA damage, … WebApr 4, 2024 · Liu, Y. et al. NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death. Proc. Natl Acad. Sci. USA 115 , 12034–12039 (2024). hcfc apes
Rotenone - an overview ScienceDirect Topics
WebThe results indicate that rotenone induction of H₂O₂ inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent apoptosis in … WebOct 1, 2024 · Noxa is a downstream signal of the p53 family, and an important pro-apoptotic factor, and a therapeutic strategy involving Noxa activation to induce apoptosis has recently been reported [24,25,26]. WebOct 9, 2014 · The results indicate that rotenone induction of H 2 O 2 inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent … hcf cash back